Limbic encephalitis with mGluR5 antibodies and immunotherapy-responsive prosopagnosia.
نویسندگان
چکیده
منابع مشابه
Spontaneous remission without progression to limbic encephalitis in a patient with LGi1 seropositive faciobrachial dystonic seizure
Faciobrachial dystonic seizures are pathognomonic of leucine-rich glioma inactivated-1 (LGi1) antibody, non-paraneoplastic limbic encephalitis. Faciobrachial dystonic seizures usually precede limbic encephalitis by about a month. It is unknown whether, if untreated, faciobrachial dystonic seizures inevitably progress to limbic encephalitis. We present an LGi1 seropositive patient with a year’s ...
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Patients with limbic encephalitis usually present with new onset mesial temporal lobe seizures, progressive memory disturbance, and a variety of other behavioral, emotional, and cognitive changes. Autoimmune inflammation of the limbic gray matter structures of the human brain has recently been identified as major cause of mesial temporal lobe epilepsy with interictal temporal epileptiform activ...
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N-methyl-D-aspartate receptor (NMDAR) antibody encephalitis is a recently described immunotherapy-responsive panencephalitis with characteristic features that include a psychiatric onset and a later movement disorder. This entity was first described as a paraneoplastic phenomenon in young women with ovarian teratomata. However, more recently it has become clear that the majority of patients, pa...
متن کاملAntibodies to metabotropic glutamate receptor 5 in the Ophelia syndrome.
OBJECTIVE To report the metabotropic glutamate receptor 5 (mGluR5) as the autoantigen of antibodies from 2 patients with Hodgkin lymphoma (HL) and limbic encephalopathy (Ophelia syndrome). METHODS Immunohistochemistry with brain tissue and cultures of rat hippocampal neurons were used to demonstrate antibodies. Immunoprecipitation, mass spectrometry, and mGluR5-null mice served to identify th...
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Background: Autoimmune limbic encephalitis is presented with the involvement of limbic structures. It is a diff erent entity rather than a component of paraneoplastic limbic encephalitis. In recent years, limbic encephalitis cases with immune-mediated voltage gated potassium channel antibody that respond to immunotherapies have been described. Case reports: We present two male patients aged 45 ...
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ورودعنوان ژورنال:
- Neurology
دوره 83 15 شماره
صفحات -
تاریخ انتشار 2014